Surgical approach to l-dopa-induced dyskinesias.
Identifieur interne : 001590 ( Main/Exploration ); précédent : 001589; suivant : 001591Surgical approach to l-dopa-induced dyskinesias.
Auteurs : Tejas Sankar [Canada] ; Andres M. LozanoSource :
- International review of neurobiology [ 0074-7742 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- methods : Deep Brain Stimulation, Neurosurgery.
- physiology : Basal Ganglia.
- surgery : Dyskinesia, Drug-Induced.
- Humans.
Abstract
Many patients treated chronically with l-dopa for Parkinson disease (PD) become functionally disabled by l-dopa-induced dyskinesias (LID). Evolved from early empirical procedures, modern stereotactic surgical lesioning techniques and deep brain stimulation (DBS) can effectively treat LID while simultaneously improving the cardinal motor symptoms of PD. Here we review the common surgical targets used to treat LID, and compare their relative efficacy. We explain the anti-dyskinetic action of surgery at each of these targets based on evolving models of basal ganglia function. Finally, we discuss the appropriate selection of patients with LID for surgery and address relevant technical and management issues in these patients.
DOI: 10.1016/B978-0-12-381328-2.00006-7
PubMed: 21907086
Affiliations:
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Le document en format XML
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Lozano</name></author></analytic><series><title level="j">International review of neurobiology</title><idno type="ISSN">0074-7742</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (adverse effects)</term><term>Basal Ganglia (physiology)</term><term>Deep Brain Stimulation (methods)</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Dyskinesia, Drug-Induced (surgery)</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Neurosurgery (methods)</term><term>Parkinson Disease (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Neurosurgery</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Basal Ganglia</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many patients treated chronically with l-dopa for Parkinson disease (PD) become functionally disabled by l-dopa-induced dyskinesias (LID). Evolved from early empirical procedures, modern stereotactic surgical lesioning techniques and deep brain stimulation (DBS) can effectively treat LID while simultaneously improving the cardinal motor symptoms of PD. Here we review the common surgical targets used to treat LID, and compare their relative efficacy. We explain the anti-dyskinetic action of surgery at each of these targets based on evolving models of basal ganglia function. Finally, we discuss the appropriate selection of patients with LID for surgery and address relevant technical and management issues in these patients.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Sankar, Tejas" sort="Sankar, Tejas" uniqKey="Sankar T" first="Tejas" last="Sankar">Tejas Sankar</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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